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KMID : 1200020210450060954
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Diabetes & Metabolism Journal
2021 Volume.45 No. 6 p.954 ~ p.959
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Long-Term Glycaemic Durability of Early Combination Therapy Strategy versus Metformin Monotherapy in Korean Patients with Newly Diagnosed Type 2 Diabetes Mellitus
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Yoo Soon-Jib
Chang Sang-Ah
Sohn Tae-Seo
Kwon Hyuk-Sang
Lee Jong-Min
Moon Sung-Dae
Proot Pieter
Paldanius Paivi Maria
Yoon Kun-Ho
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Abstract
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We assessed the glycaemic durability with early combination (EC; vildagliptin+metformin [MET], n=22) versus MET monotherapy (n=17), among newly-diagnosed type 2 diabetes mellitus (T2DM) enrolled (between 2012 and 2014) in the VERIFY study from Korea (n=39). Primary endpoint was time to initial treatment failure (TF) (glycosylated hemoglobin [HbA1c] ≥7.0% at two consecutive scheduled visits after randomization [end of period 1]). Time to second TF was assessed when both groups were receiving and failing on the combination (end of period 2). With EC the risk of initial TF significantly reduced by 78% compared to MET (n=3 [15%] vs. n=10 [58.7%], P=0.0228). No secondary TF occurred in EC group versus five patients (29.4%) in MET. Patients receiving EC treatment achieved consistently lower HbA1c levels. Both treatment approaches were well tolerated with no hypoglycaemic events. In Korean patients with newly diagnosed T2DM, EC treatment significantly and consistently improved the long-term glycaemic durability as compared with MET.
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KEYWORD
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Diabetes mellitus, type 2, Drug therapy, combination, Glycated hemoglobin A, Korea, Metformin, Vildagliptin
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